The Methodist Congregations was established in Puerto Rico by missionary Charles W. Drees in 1900 shortly after the US occupation.  The Holy Trinity Cathedral was commissioned to Nechodoma in 1921 and is one of several designs that Nechodoma did for the Methodist Church in Puerto Rico which include the McCabe Memorial Church, Our Lady of Lourdes Chapel, the First United Methodist Church in Ponce, the Arroyo Methodist Church and the Collins Missionary Rest Home in Aibonito.

 For this design, Nechodoma resorted to the Mission Style.  It is interesting to note that this Church is ten feet back from the sidewalk in order to create an entrance garden.  In Old San Juan, this would normally violate the traditional urban design of the colonial city given the fact that all other structures in the area respect the urban wall of the street.  This small design difference makes the façade more perceptible and easier to appreciate.

It is located at Calle Sol #103 in Old San Juan.