Lozano, Pendas & Co. was established in 1867 by Faustino Lozano (1842-1906) who always lived in Brooklyn, and Ysidro Pendas Garcia (1844-1902). Faustino Lozano was a Spanish immigrant from Asturias who arrived in New York City in 1865 and in 1868 married Cornelia Hogan (1846-1911) who had emigrated from Ireland in 1858.  They had five children; Gabriel (1869-1893), Faustino C. (1877-1916), José Maria (1885-1940), Mary (1875-1950) and Ramona (1879-1952). Ysidro Pendas Garcia was a Spanish immigrant from the village of Priero in Asturias who emigrated to Cuba in 1860 and learned the cigar business there while working at La Sultana factory. 

The book The Eagle and Brooklyn published in 1892 includes a review of Ysidro Pendas Garcia in its Men of the Time section.  Therein it is stated that:

"In 1867 with Faustino Lozano and Miguel Alvarez he formed the firm Lozano, Pendas & Co., Pendas being the business name of Mr. Garcia.  Beginning in Brooklyn and continuing in New York, the house made successive advances in prosperity, the opportunities and requirements of its business finally leading to the establishment of a branch at Key West, Florida which was subsequently transferred to Tampa, where there is now a large plant, built and owned by the firm."

Lozano, Pendas & Co. was the third factory established in Ybor City on May 15, 1887 right after Vicente Martinez Ybor and Ignacio Haya established theirs in 1886. The 1892 Sanborn Fire Insurance Map shows the location of Lozano Pendas & Co. cigar factory building at the northwest corner of 10th Ave. (today Palm Ave.) & 15th St. , adjacent to where the Cyrilla cigar factory building was later built. Ysidro's brother Enrique Pendas Garcia (1846- ) and nephew Enrique Pendas Trelles (1865-1935) the son of Manuel Pendas Garcia and Serafina Trelles, were also members of Lozano, Pendas & Co. Other family member that formed part of the company during its early days were Enrique Pendas Trelles brother Jaime Pendas Trelles (1863-1936) and Anastacio Alvarez, brother of Miguel Alvarez. 

The Enrique Pendas Trelles life history available at the Library of Congress typed in first person by Enrique states:

“Just before establishing our factory in Tampa, I went to Key West and remained there for eight months.  Our factory, Lozano Pendas & Co., was finally established here on May 15th, 1887 when I was 22 years of age. I remember that when I established the factory here, I gave employment to nearly all the workers of Sanchez & Haya.”

Enrique Pendas Trelles was born in Asturias on April 12, 1865, in 1883 when he was 16 years old he left his homeland for Cuba where he lived for two years and learned the business at the Romeo & Julieta factory. He then he went to New York where he worked with his uncle Ysidro Pendás at Lozano, Pendás Cigar Co.  However, according to a passport application dated July 21, 1917 for travel to Cuba to purchase tobacco, he lived uninterruptedly in Tampa since arrival in the US which is in contradiction to his own statements in the typed life story mentioned above. In 1887 a year after the cigar industry started in Ybor City, when Lozano, Pendas & Co. decided to open a factory in Tampa, Enrique then twenty two years old, was assigned the responsibility to set up its operations.

In 1894 Faustino Lozano sold his interests in Lozano, Pendas & Co. and retired from the cigar manufacturing business to established a tobacco leaf business together with a Mr. Selgas. When Faustino sold his interest in Lozano, Pendas & Co. in 1894, the firm name was changed to Y. Pendas, Alvarez & Co.  This fact is corroborated in the document dated May 1984 titled Structure Analysis: Lozano Cigar Factory, where Bilal Sultan Ajami analyzes the F. Lozano, Son & Co. building's design. In his write up regarding the firm, he states that when Faustino Lozano sold his interest and ceased his involvement with Lozano, Pendas & Co. in 1895, the firm was absorbed into Y. Pendas, Alvarez & Co. 

In 1904, Faustino C. Lozano (Faustino Lozano's son) associated with Alejandro “Padrino” Nistal and established the firm Lozano Nistal & Co. at 1925 7th Ave. in Ybor City, today an empty lot pictured below. At this location they manufactured La Flor de Lozano and Nistal & Co. brands.  The association with Nistal ended in 1905 when Faustino Jr., together with his father and brother José Maria, decided to form their own cigar manufacturing business.  Nistal is named in a 1908 Tobacco Leaf publication as Gonzalez, Fisher & Co. superintendent. Initially a partnership, it was not until 1907 that F. Lozano, Son & Co. was incorporated in New York. Faustino Jr., who lived in New York from 1907 to 1913, ran the company until his death in 1916 when his brother José Maria took over as President.  

After completion of this 39,280 sq. ft. building in November, 1905 all machinery and equipment from the 1925 7th Ave. factory building where Lozano Nistal & Co. used to be, was moved here.  According to this Florida Historical Quarterly publication, F. Lozano, Son & Co. never recovered from the 1920 labor strike that lasted from February 1920 until April 1921. and closed operations for good in 1923 when its assets including its brand names were sold to the Morgan Cigar Co.  In 1924, Corral-Wodiska & Cia. leased the building, in 1925 the lease went to Gradiaz-Annis & Co. who occupied it until ca. 1928.  Between 1931 and 1943, M. Bustillo and Merriam Cigar were the occupants and the last to use the building as a cigar factory.  

In 1943 the property was sold to Tampa Casket Co. who used the facilities until 1969 when it filed for bankruptcy and sold the building to Oliva Tobacco Co.  The Tampa Casket Co. name can still be seen on the front of the building.  The building was later owned by George Rink who in 1984 sold it to the Norbert Fuller Construction Co. after being denied a Historic Preservation Certificate by the State of Florida in 1982.  It was leter acquired by the Lawrence Properties Group and since 2005 it is owned and occupied by Central Florida Lions Eye & Tissue Bank Inc.