According to José Ferreras Pagán in his book Biografía de las Riquezas de Puerto Rico, Hacienda Destino was established by Juan Capó and then owned by his estate.  In 1902 it consisted of one thousand eight hundred eighty cuerdas of which four hundred fifty were planted with sugarcane producing some one thousand three hundred hogsheads of sugar annually.  Then, its administrator was Vicente Balbás Capó and 1st Overseer was Enrique Mercado. The Juan Capó referred to by Ferreras Pagán is Venezuelan born of Spanish descent Pedro Juan Capó Planchart (1809-1874), son of Francisco Capo Coll and Caracas Venezuela born Theresa de Jesus del Carmen Planchart Rondón (1809- 1869).  Pedro Juan was married to Constanza Ortiz de la Renta (1815-1857) and was Mayor of Ponce from September to December 1856 where he always lived until his death.  

Although the date the hacienda was established is unclear, Hacienda Destino was already established by 1844 when on March 21 of that year a concession for water right was granted to Jose R. Alomar, Pedro J. Capó and N. Márquez to extract water from the Coamo River for irrigation purposes at their haciendas Santa Isabel, Destino and Florida.

Between 1846 and 1886,  the owners of haciendas Florida, Santa Isabel, and Destino agreed to finance and build an irrigation system for their three properties.  Funds for the construction came from their own money and some help from the Spanish Crown.  It consisted of a set of structures built in brick, stone and lime mortar masonry with concrete plastering to transport water from the Coamo River to the fields of their sugar cane plantations.  Identified as the "Irrigation System of the Three Haciendas", it was registered in the National Register of Historic Places on December 13, 2016.

After the death of Pedro Juan Capó Planchart, the then one thousand seven hundred twenty six acre hacienda was inherited and administered by his daughters Eufemia Capó Ortiz de la Renta (1847-1918) who married Francisco Parra Duperón, Matilde Capó Renta (1835-1902) who married Pedro Juan Rosaly Ascencio and Ursula Capó Renta(1835-1913) who married Francisco Arce Romero.  The hacienda continued to operate under the name Sucn. Capó until the first few years of the 1900s when Hacienda Destino stopped processing and sent all sugarcane grown on it lands to be processed at the recently established Central Aguirre. 

Hacienda Destino remained in the Capó family until 1920 when it was acquired by Luce & Co., a subsidiary of Central Aguirre.  In 1964 some one thousand twenty acres of land of the former hacienda were sold to farmer Pedro Ramos before the Government of Puerto Rico acquired all other lands through the Land Authority.

The masonry building pictured below, which has been altered some, was supposedly the processing plant.  It was located on the North side of PR-1, the road from Santa Isabel to Salinas, about 3 km from the town of Santa Isabel.