According to the Puerto Rico Sate Historic Preservation Office Register of Historic Places, Hacienda Media Luna in To a Baja original owner was Lt. Col. Ret. Carlos Vassallo, an Italian immigrant who arrived on the island shortly after the Royal Decree of Graces of 1815.  By 1847 Vassallo was already a plantation owner per the 1847 baptismal records of the children of three of his slaves which so state.  The register indicates the manor house was built in 1849 and the existing chimney, located approximately one mile south of the house, is reportedly from 1861.

In her book Capitalism in Colonial Puerto Rico, Teresita Martinez-Vergne states that in November 1870 Leonardo Igaravidez lent Gervasio Medina Altualde, then owner of Hacienda Media Luna, the sum of 32,000 pesos to finance that year's crop.  Several sources report that Hacienda Media Luna was established by Cipriano Nevares as a sixty acre plantation.  No birth or death dates were found for Cipriano but based on the birth dates of his son José Nevares Rivera (1804-1863), he must have established the hacienda in the late 1700s or early 1800s.  That being the case, and if the hacienda always remained in the Nevares family, there is no explanation for the statement by Martinez-Vergne it was owned by Gervasio Medina in 1870.

The history, years of operation and chain of ownership of Hacienda Media Luna  are not stated in José Ferreras Pagán 1902 book Biografía de las Riquezas de Puerto Rico as he states its then owner, José Nevares, denied providing any information.  He does state that it was no longer in operation and sugarcane grown on its land was processed at the nearby Central Constancia.  He also states that the sugar factory facilities at Hacienda Media Luna were in a bad state of disrepair and some of its original land holdings were leased to Central La Luisa in Manatí.

José Ignacio Nevares Rivera (1804-1863) supposedly inherited the hacienda after Cipriano's death.  José Ignacio and his wife Maria Ramona Marrero Rivera (1799-1856) had five children: Maria Genara Nevares Marrero (1831-1863), Maria de las Nieves Nevares Marrero (ca.1834- ), Ceferino Nevares Marrero (1837-1893), Francisco Nevares Marrero (1840-1925) and Jacinto Nevares Marrero (1842-1914).  It appears that after José Ignacio Nevares Rivera's death in 1863, the hacienda was owned by his estate and managed by his eldest son under the business name Ceferino Nevares & Hno.  The firm ran into excessive debts and became insolvent, so on June 27, 1882 Ceferino Nevares Marrero, who was its administrator, acquired a majority interest in a transaction that included the acquisition of his sibling’s participation and a promise to pay all creditors.

Ceferino Nevarez Marrero married Maria Dolores Landrón Arnau (1842-1872) and had four children; Rita Nevares Landrón (1866-1903), Rafaela Nevares Landrón (1868-1940) who married Luis Izquierdo Serrano, José Maria “Pepe” Nevares Landrón (1863-1928) who married Petronila López Martinez (1860-1911) and Felisa Nevares Landrón. After the death of Maria Dolores, on September 1872 Ceferino married French immigrant from Aldudes, Pyrénées-Atlantiques, France Marie Mococain (1847-1879) and had two children, Maria Juana Nevares Mococain (1876- ) and Ceferino Nevares Mococain (1877-1909). José and Petronila had eight children: Rafael Nevares Lopez (1884-1966), Mario Nevares Lopez (1886-1920), Oscar Nevares Lopez (1887- ), Dolores Nevares Lopez (1889-1918), Jose Tomás Nevares Lopez (1893-1944), Ramón Nevares Lopez (1895- ), Jorge Nevares Lopez (1900-1982) and Roberto Enrique Nevares Lopez (1904-1919).  After the death of Petronila, José married Mercedes de la Torre Berrios (1857- ) on September 6, 1914 with whom no children were procreated. In September 1905, Ceferino's son José María Nevarez Landrón acquired full ownership of the hacienda when he purchased José Pons Bernard interest in Media Luna, interest that Pons had acquired in lieu of payment of debt. 

Although not inherent to the history of Hacienda Media Luna, there are a several interesting facts about the Nevares family. 

• In 1911, Rafael Nevares Lopez married Inés Guillermety Romañat and among their children was Hector Guillermo Nevarez Guillermety (1916-2013) who in 1942 established Suiza Dairy.  Today lands of Hacienda Media Luna that once were used to grow sugarcane are cow pastures/dairy farm related to the family's Suiza Dairy operations. 

• Oscar Nevarez López married Margarita del Valle Olmedes (1892-1989) on August 8, 1912 and had two children: Francisca Nevares del Valle (1914-2011) and Oscar Nevares del Valle (1918- ).  After Oscar divorced Margarita, on September 1927 he married Ena Luisa de la Baume Marini (1907-1999) whose family owned Hacienda Boquerón.

• Francisca (Frances) Nevares del Valle, the daughter of Oscar Nevares Lopez and Margarita del Valle Olmedes, married Felix Juan (Fao) Serrallés Sanchez (1911-1985) member of the Serrallés family owners of Central Mercedita in Ponce. 

• Oscar Nevarez del Valle married Irma Padilla Rodriguez and their daughter Irma Margarita (Maga) Nevares Padilla married Dr. Pedro Roselló Gonzalez who was Governor of PR from 1993 to 2001.  Pedro and Irma Margarita were the parents of Ricardo Roselló Nevares, also Governor of PR. from 2017 to 2019.

Today, the manor house belongs to Oscar Nevares Padilla, the brother of Irma Margarita.